Amiloride-Sensitive Sodium Channels: Physiology and by Dale J. Benos

By Dale J. Benos

Sodium reabsorbing epithelia play a huge function in whole-body sodium homeostasis. a few examples of sodium regulating tissues contain kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step procedure: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for shipping and are regulated via numerous assorted hormones. The sodium channels additionally play an important function in a few sickness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and sensible Diversity presents the 1st in-depth alternate of rules touching on those sodium channels, their rules and involvement in basic and pathophysiological situations.

  • Summarizes present country of amiloride-sensitive sodium channel field
  • Analyzes structure-function of epithelial sodium channels
  • Discusses immunolocalization of epithelial sodium channels
  • Examines hormonal law of sodium channels
  • Discusses sodium channels in lymphocytes, kidney, and lung
  • Considers mechanosensitivity of sodium channels
  • Provides rules on sodium channels and disease

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